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When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)

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Mitochondrial Vulnerability: Mitochondria cannot synthesise glutathione and depend entirely on membrane transporters for supply

For long-term storage, freezing is recommended